SCIENTIFIC AND RESEARCH WORK

Topic of the scientific and research work at the Department of Physical and Colloidal Chemistry is "Research of synthetic, physical-chemical and biological properties of derivatives of 5-aryl- and 5-heteryl-4-R-3-thio(amino)-1,2,4-triazoles" from 01.2018 to 12.2022.

During scientific and research work is carried out:

  • synthesis of about 500 new compounds of 5-aryl, heteryl-1,2,4-triazole-3-thione for which a wide range of biological effects is being studied and, based on the results obtained, to establish the laws of the substitution effect on biological activity.
  • conducting research on the establishment of physical and chemical constants for all synthesized compounds, including the constants of acid and base, etc.
  • carrying out chromatography works and confirmation of molecular mass and structure of new biologically active substances.
  • planning and defense of 3 candidate's theses, 15 master's and thesis papers.
  • development of draft normative and technical and technological documentation for the most active compounds.
  • coverage of the results at the International and Ukrainian scientific-practical conferences and their publication in articles.
  • introduction of research results in the scientific and pedagogical process of the departments of higher medical and pharmaceutical universities.

 

All research in the department's SRW is carried out in accordance with the established plan in the synthetic, physical-chemical and chromatographic laboratories of the faculty of Physical and Colloidal Chemistry, as well as at the departments of ZSMU and other institutions, namely:

  • Educational Scientific-Production Laboratory;
  • Department of Pharmacology and Medical Recipes;
  • Department of Pharmacognosy, Pharmacology and Botany;
  • Department of toxicological and inorganic chemistry;
  • Department of Organic and Bioorganic Chemistry;
  • Department of Microbiology and Virology;
  • State Scientific Institution "Scientific-technological complex "Institute of Single Crystals" of the National Academy of Sciences of Ukraine»
  • Limited Liability Company «Rubіzhans'kij barvnik»

 

On the theme of SRW of the Department of Physical and Colloidal Chemistry, the candidate's dissertations were executed and defended:

Senior teacher Shcherbak Maryna Oleksiivna

Topic: "Research of synthetic, physical, chemical and biological properties of 4-amino-5-(2-, 3-, 4-nitrophenyl)-1,2,4-triazole-3-thione and their N- and S-substitutes".

Assistant Sameliuk Yurii Hennadiiovych

Topic: "Synthesis and study of biologically active derivatives of 1,2,4-triazole-3-thione containing methoxyphenyl substituents"

Assistant Kucheriavyi Yurii Mykolaiovych

Topic: "Synthesis, modification and properties of 5-(phenoxymethylene)-4-R-1,2,4-triazole-3-thiones and their derivatives"

 

Planned candidate's theses:

Assistant Frolova Yuliia Serhiivna

Topic: "Creation of new biologically active compounds in the series of 5-(1H-tetrazole-1-yl)-4-R-3-thio(amino)-1,2,4-triazole"

Duration: 09.2016 – 09.2020

The research work is also carried out by alumni and students of our university, working in the scientific circle of the department.

 

The department conducts research on a wide spectrum of pharmacological research in relation to new synthesized compounds, which have been resulted in the selection of the most active substance, namely morpholin 2-(5-(4-pyridyl)-4-(2-methoxyphenyl)-1,2,4-triazole-3-ylthio)acetate. On the basis of this substance a potential original low-toxic neuroprotective drug with adaptogenic properties "TIOMETRYZOL" has been created with antioxidant and anti-ischemic mechanism of action, which has significant neuroprotective properties. The drug is relevant and necessary, since cerebral stroke is currently one of the main causes of death and disability in the world

НАУКОВО-ДОСДІДНА РОБОТА КАФЕДРИ ФІЗКОЛОЇДНОЇ ХІМІЇ НАУКОВО-ДОСДІДНА РОБОТА КАФЕДРИ ФІЗКОЛОЇДНОЇ ХІМІЇ

Chromatographic studies on the department of physical and colloidal chemistry

The laboratory for liquid chromate-mass-spectrometry at the Department of Physical and Chemical Chemistry began its work in February 2014. The leading specialist is the PhD, Associate Professor, Varynskyi Borys Oleksandrovych .

 

The laboratory for liquid chromate-mass-spectrometry performs research on:

  • establishment of purity and confirmation of the molecular weight and structure of new biologically active substances synthesized in order to find new drugs;
  • investigating the processes of adsorption, distribution, metabolism and excretion of medicinal substances.
  • determination of biologically active substances in medicinal plant extract extracts.

 The laboratory is equipped with the Agilent 1260 Infinity HPLC System hardware (degasser, binomial pump, autosampler, column thermostat, diode-matrix detector, single-quadrupole mass spectrometer Agilent 6120 with ionization in electric field) and software Open LABCDS Software.

 

At present, the laboratory of the Department of Physical and Colloidal Chemistry conducts research for many departments of the ZSMU:

  • Department of toxicological and inorganic chemistry;
  • Department of Organic and Bioorganic Chemistry;
  • Department of Biochemistry and Laboratory Diagnostics;
  • Department of Pharmacognosy, Pharmacology and Botany;
  • Department of Pharmacognosy, Pharmaceutical Chemistry and Technology of Pharmaceuticals;
  • Department of Normal Physiology;
  • Department of Pathological Anatomy.

Today is already published: 2 review and more than 15 experimental articles.

Хроматографічні дослідження на кафедрі фізколоїдної хімії Хроматографічні дослідження на кафедрі фізколоїдної хімії

Student scientific society

Artamonov Valeriy – a student of the 4th year Pharmaceutical faculty, is engaged in physical and chemical studies of derivatives of 1,2,4-triazoles, quantum chemical calculations of synthesized molecules.

Bliznyuk Denis is a 3rd year student at the Pharmaceutical faculty, from the first year he has been an active participant in the SSS of the Department of Physical and Colloidal Chemistry. He is engaged in physical and chemical studies of derivatives of 1,2,4-triazoles, quantum chemical calculations of  synthesized molecules, conducts preliminary computer screening of biological activity of synthesized compounds.

Dovbnya Dmitry is a 3rd year student at the Pharmaceutical faculty. Since his fist year he has been an active participant in the SSS of the Department of Physical and Colloidal Chemistry. He is engaged in physical and chemical studies of derivatives of 1,2,4-triazoles, quantum chemical calculations of  synthesized molecules, conducts preliminary computer screening of biological activity of synthesized compounds.

Usenko Dmitry is a 2nd year student at the Pharmaceutical faculty. He engaged in physical and chemical studies of derivatives of 1,2,4-triazoles.

Guliy Andriy is a 3rd year student at the Pharmaceutical faculty working in the laboratory for liquid chromate-mass-spectrometry. Performs sample preparations of compounds for HPLC, calibration of equipment, preparation of solutions with exact concentrations.

Vitaliy Golovkin is a 3rd year student at the Pharmaceutical faculty working in the laboratory for liquid chromate-mass-spectrometry. Performs sample preparations of compounds for HPLC, calibration of equipment, preparation of solutions with exact concentrations.

 

Student scientific facility of the faculty of physical and colloidal chemistry

 

The SST of the Department of Physical and Chemical Chemistry of the Zaporizhzhya State Medical University functions on the basis of three laboratories, the purpose of which is to study the synthetic, physical, chemical and biological properties of synthesized chemicals, new potential medicines based on the nucleus of 1,2,4-triazoles.

Students belonging to the department of Physical and Chemical Chemistry are directly involved in the scientific activity of the department. All students acquire basic knowledge and skills in the chemical and analytical laboratories, as well as regulations for experiments with laboratory animals.

Students who take part of the CHS faculty of the Physiological Chemistry, during the year speak at student conferences (both domestic and foreign), traditionally take part in the All-Ukrainian contest of student research papers, and scientific and practical events held on the basis of Zaporizhzhya State Medical University and outside of it.

Студенти учасники СНТ Студенти учасники СНТ